Río San Francisco Vacations from $773

Book a Hotel + Flight or Car together to unlock savings

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

The Latest Río San Francisco vacation packages

Price found within the past 48 hours. Click for updated prices.

LOFT Hotel by Sommelier Hoteles

Downtown Santiago

$773

per person

Dec 3 - Dec 9

found 18 hours ago

Roundtrip non-stop flight included

Guatemala City (GUA) to Santiago (SCL)

9/10 Wonderful! (269 reviews)

Aubrey Hotel Boutique

Bellavista

Save 100% on your flight

$1,056

per person

Nov 13 - Nov 20

found 1 day ago

Roundtrip flight included

Guatemala City (GUA) to Santiago (SCL)

9.4/10 Exceptional! (152 reviews)

Casa Bueras Boutique Hotel

Downtown Santiago

$1,232

per person

Nov 13 - Nov 20

found 1 day ago

Roundtrip flight included

Guatemala City (GUA) to Santiago (SCL)

9.2/10 Wonderful! (557 reviews)

ICON Hotel

Las Condes

$903

per person

Dec 3 - Dec 9

found 18 hours ago

Roundtrip non-stop flight included

Guatemala City (GUA) to Santiago (SCL)

8.6/10 Excellent! (1,003 reviews)

Fantastic vibes

Reviewed on Sep 18, 2026

Hotel Nodo - El primer hotel de negocios en Chile

Providencia

$869

per person

Dec 3 - Dec 9

found 18 hours ago

Roundtrip non-stop flight included

Guatemala City (GUA) to Santiago (SCL)

8.6/10 Excellent! (125 reviews)

Hotel perfeito, limpo e os funcionários muito atenciosos.

Reviewed on Sep 3, 2026

Don't see what you're looking for?

See all available trips from Columbus to Río San Francisco

View all trips

Stay near popular Río San Francisco attractions

Farellones

Enjoy the thrill rides with your kiddos at Farellones during your trip to Lo Barnechea. Discover the area's sunsets and spas.

See properties

What to do in Río San Francisco

Santiago: Portillo and Laguna del Inca Day Trip with Picnic

$54

per adult

Santiago: Concha y Toro and Undurraga Vineyards Tour

$76

per adult

100% of travellers recommend

Santiago: Full day panoramic tour to ski resort Valle Nevado

$55

per adult

See all activities in Río San Francisco

Río San Francisco Hotel Deals

Gran Parador Apartments Ski Center El Colorado Farellones.

503 El Colorado Lo Barnechea Región Metropolitana

$298 nightly

$298 total

Sep 27 - Sep 28

8.4/10 Very Good! (47 reviews)

"Worst experience because of the poor communication from the people at the front desk. They send you to a restaurant next door promising a discount that never happens. The waitresses there lack manners, professionalism, and they even steal from you. I'm never coming back."

Reviewed on Sep 21, 2026

Mandarin Oriental, Santiago

Kennedy Avenue #4601 Santiago Region Metropolitana

Fully refundableReserve now, pay when you stay

$269 nightly

$269 total

Sep 25 - Sep 26

9.4/10 Exceptional! (1,002 reviews)

"Fantastic room, very helpful staff, excellent food"

Reviewed on Sep 22, 2026

Hotel Plaza San Francisco

Alameda 816 Santiago Region Metropolitana

Fully refundableReserve now, pay when you stay

$134 nightly

$134 total

Oct 17 - Oct 18

See all 2,444 properties in Río San Francisco

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.